• Die Zukunft mitgestalten

    Die Hector Fellow Academy stößt innovative Forschungsprojekte in neuen wissenschaftlichen Fragestellungen an.

Genetic & Developmental Basis of Color in Cichlid Fish

Margaret Sefton – Hector Fellow Axel Meyer

Diese Arbeit konzentrierte sich auf die genetischen Grundlagen der Anpassung und Diversifizierung von Buntbarschen durch die Untersuchung von Genen, die an der Entwicklung von Farbmustern beteiligt sind. Die Kombination von Modellsystemen aus dem Bereich Ökologie und Evolutionsbiologie mit den abgewandelten Techniken eines Genmodellorganismus erlaubte die Überprüfung von Hypothesen über die Beteiligung bestimmter Gene an der Evolution neuer Arten.

Cichlid fish* are well-known for their beautiful colors and multitude of body shapes. They are found in the East African Rift lakes where they have formed so-called adaptive radiations, in which hundreds of new species originated extremely quickly – sometimes within less than 100,000 years. This thesis, under the supervision of Hector Fellow Axel Meyer, focuses on the genetic basis of adaptation and diversification in cichlids by examining genes involved in color pattern development.

In the first project the regulatory basis of coloration in several species of cichlids is investigated. Using next-generation sequencing technologies, it will be searched for genes that might cause the differences between various cichlid species and characteristics that differ between males and females. One of the main research questions concerns the relative roles of structural changes (the emergence of new genes) and regulatory changes (existing genes used in a new developmental context) during the process of divergence.

The second project, developing an experimental framework for the in vivo testing of gene function in the Midas cichlid, will use innovative genome engineering approaches.

By combining a model system from the fields of ecology and evolutionary biology with techniques adapted from genetic model organisms, such as the zebrafish, novel hypotheses about the involvement of specific genes in the evolution of new species will be tested – something even Darwin could not have dreamed of.

*) In German Buntbarsche