Genetics and Epigenetics of Posttraumatic Stress Disorder and its Treatment
Daniela Conrad – Hector Fellow Thomas Elbert
The risk to develop posttraumatic stress disorder (PTSD) depends on the number of traumatic events experienced and individual risk factors, e.g. genetic predispositions. However, to identify causal genetic variants of this polygenic disease, trauma exposure needs to be adequately assessed. Furthermore, previously used candidate gene and genome-wide studies rarely presented with sufficient statistical power to detect the marginal effects of single genetic markers, making a combination with other more suited approaches necessary. Moreover, prior research indicated epigenetic modifications (i.e. biological mechanism influencing gene regulation and expression) to be risk factors for PTSD and potential predictors of treatment success.
This PhD project, supervised by Hector Fellow Thomas Elbert, aims to systematically investigate the interplay between trauma exposure, genetic pathways and their epigenetic modification in terms of PTSD development in a large sample of survivors of the rebel war in Northern Uganda. Furthermore, the project explores, whether methylation of epigenetic sites predicts treatment success after a trauma-focused treatment approach (Narrative Exposure Therapy, NET) and whether methylation patterns change from pre to post-treatment (see Figure).
A better understanding of genetic and epigenetic risk and resiliency factors in the etiology and treatment of PTSD will contribute in the long run to improved psychotherapeutic and pharmacological treatments for PTSD.
Stress & Epigenetik: Wie Fische zur Behandlung posttraumatischer Belastungsstörungen beitragen – Ein interdisziplinäres Forschungsprojekt von Prof. Dr. Axel Meyer & Prof. Dr. Thomas Elbert
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