Photocatalysis and Transition-Metal-Catalyzed Reactions of Furane-Derivatives
Daniel Eppel – Hector Fellow A. Stephen K. Hashmi
Fossil resources are increasingly depleted. They have to be replaced as quickly as possible by renewable raw materials, so that a slow transition to a new and modern production of "platform chemicals" can take place.
The project supervised by Hector Fellow A. Stephen K. Hashmi aims on the rational development of sustainable, waste-minimized and environmentally friendly conversions of furan-derivatives with olefins. Reaction conditions have to be found, which favor the [4+2]-cycloaddition of the starting materials to the respective 7-oxanobornene derivatives. Based on previous work in the Hashmi group with diazonium salts, the conversion of furan derivatives are investigated. In this case gold-catalyzed photoreactions achieve activation and induce a new bond formation.
Furthermore, reaction conditions have to be found which enable Murai reactions with yet unreactive furfural or furan derivatives at their C3-positions. This reaction type has so far only been carried out with ketones as a directing group. In the course of this Ph.D. project, it will be investigated whether aldehydes or even other functional groups are capable of C-C bond formation at the C3 position. With these reactions, in addition with some further ideas, chemicals derived from non-nutritionally relevant raw materials can be used to create value. With the help of atom-economical and with regard to the principles of "green chemistry" fulfilling syntheses, building blocks for natural or medicinal products are to be developed.