• Die Zukunft mitgestalten

    Die Hector Fellow Academy stößt innovative Forschungsprojekte in neuen wissenschaftlichen Fragestellungen an.

Stress & Epigenetics: Epigenetic effects of parental stress in offspring

Dr. Amber Makowicz - Hector Fellow Axel Meyer

Im Zentrum des Projekts steht der Einfluss von umgebungsbedingtem Stress auf epigenetische Veränderungen der Genexpression. Am Modell von Fischen wird der Einfluss von Stress bei Eltern auf langfristige maladaptive Verhaltensänderungen in den Folgegenerationen erforscht.

In diesem Projekt forschen die Hector Fellows Thomas Elbert und Axel Meyer zusammen mit der Postdoktorandin Dr. Amber Makowicz (Universität Konstanz).

Chronic stress has been related to major mental disorders through changes in the HPA axis (an important stress response found in all vertebrates) and is most notable through changes in DNA methylation. The most common mental disorders that occur from chronic stress are depression and anxiety, although other psychopathological disorders may also occur. Mothers are thought to be the primary influencer of offspring development, especially in regards to neurodevelopment. Evidence is mounting that suggests that some of these epigenetic effects may even be transmitted transgenerationally and would thus be directly affecting evolution.

Poeciliids as a Model System

Poeciliids are great models to test the effects of stress: they are small, livebearing fish that have short generation times. There is no parental care in any of the species, which provides a perfect control for the potential influence of parental behaviors on the offsprings’ behaviors. Most importantly, however, is that some species are matrotrophic featuring a placenta-like structure and are able to transfer additional nutrients to offspring during pregnancy, while others are lecitotrophic and show no additional maternal transfer beyond the yoking of the egg.

The goal: To test the effects of stress on long-lasting maladaptive behavioral changes in offspring of stressed parents and determine how long these changes might be transmitted to subsequent generations. This research will allow us to better understand how environmental stressors influence gene expression and behaviors of offspring.



Stress & Epigenetik: Wie Fische zur Behandlung posttraumatischer Belastungsstörungen beitragen – Ein interdisziplinäres Forschungsprojekt von Prof. Dr. Axel Meyer & Prof. Dr. Thomas Elbert

Mehr Videos der Hector Fellow Academy auf YouTube.